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Posts tagged ‘supplements’

Healthy lifestyle habits that put you at risk for undesirable side effects

We live in a global environment: any news flies around the planet in seconds and that includes fake promises, expectations and lies about healing miracles. It is quite difficult to distinguish between scientifically proven truth and assumptions on which many potential cures are based.

Why does that happen? We have to understand that in nowadays profit-taking world it is not consumers’ health that always comes first. While many companies which intend to manufacture health promoting products start out honestly, there are also very many companies that use the consumers’ trust in miracles in their favor. TV and media advertising do not promote only good and well-tested products: they will advertise anything that looks like it might be true and brings in money.

Considering the epidemic obesity rates, which include early childhood and young age obesity, abnormally high numbers of patients with cardiovascular and cerebrovascular, as well as heart diseases, not to mention cancer epidemics, people need something promising. TV, phone, laptop and computer screens scream to us: vitamins and supplements are the answer!

This era is also characterized by extreme efforts trying to maintain youthful look and energy, as well as live and stay active longer. There was no long-term research present when the first statements about the beneficial use of synthetic vitamins and supplements as our daily routine were made publicly available. Since the naturally occurring vitamins, amino acids and minerals played such an important role in functioning of our body and mind, it was simply believed that more of these nutrients are better. It was believed that the source of these nutrients was not the most important aspect.

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For how many decades now have you heard from your doctor: just take some multivitamins, use omega-3 or fish oils, don’t forget vitamin C and E; obviously we all suffer from lack of vitamin D and calcium, so these should not be forgotten either? That has become such an indisputable healthy life-style feature that you will find hardly any person in the developed countries who hasn’t been on lots of vitamins and supplements at some moment of their life.

The CONCERN ABOUT OVERUSE OF SYNTHETIC VITAMINS and SUPPLEMENTS is growing with every new clinical trial that has been carried out to observe whether there are any significant benefits from such synthetic supplement use. The findings are shocking at some point. While almost everybody knows by now that multivitamin use did not result in any health benefits, not everybody is still aware that over-the-counter supplements do not do what they are supposed to, as well.

Millions of people reach every day for their calcium or vitamin D3 pill, or combination thereof.  Here is a quote from Science Daily (summary of a clinical trial): “Taking calcium in the form of supplements may raise the risk of plaque buildup in arteries and heart damage, although a diet high in calcium-rich foods appears be protective, say researchers at conclusion of their study that analyzed 10 years of medical tests on more than 2,700 people.”

https://www.sciencedaily.com/releases/2016/10/161011182621.htm

Almost everybody over 50 believes that taking calcium supplements will aid in avoiding bone fractures and loss of bone mass and its mineral density: osteoporosis. That is not the only review; there are quite a few clinical trial conclusions that state the same: calcium in the form of a synthetic supplement does not provide with the same effects as consumption of dietary calcium, calcium naturally occurring in food products.

Meticulous testing showed that most of calcium taken as supplements did not even get to the bones: it was partially excreted with urine (hypercalciuria was quite common among calcium supplement users) and also calcium spikes were observed which does not happen with calcium-rich food intake. Judging by tests which showed no improvement with bone density, researchers believe that the other part of synthetic calcium dose is absorbed by soft tissue which explains arterial plagues and calcification of arteries. Calcium spikes were also responsible for heart conditions. Strokes and coronary artery blockages occurred much more frequently in those taking high doses of synthetic calcium supplements. Moreover, there was not observed decrease in fractures or osteoporosis.

Journal of the American Heart Association  https://www.sciencedaily.com/releases/2016/10/161011182621.htm

Quote: “Because of the widespread awareness and treatment of osteoporosis with calcium supplements among older adults, this population would appear to be at greater risk of developing the adverse consequences of positive calcium balance, including vascular calcification.”

 “Calcium may be involved in pathogenesis of CVD (cardiovascular diseases) through multiple pathways, including through influences in lipid metabolism, insulin secretion and sensitivity, inflammation, thrombosis, regulation of body weight, and vascular calcification.”

The same goes for so much widely popularized omega-3 or healthy fatty acids. The evidence from many clinical trials exploring different conditions, such as omega-3 effects on cardiovascular and heart diseases, strokes and heart attacks, impact on brain function and delays of age-related dementia, rheumatoid arthritis and quite a few others, is very unconvincing. The widespread assumption that fatty acids may help delaying onset of some heart conditions, eye degeneration, brain malfunction and prevent cancers has no strong scientific evidence. It was noted that people who lived far north and consumed mostly fish suffered less from the above mentioned conditions. It wasn’t taken into account that their physical loads may be way different or their environment might be almost pollution-free. Therefore, it was soon assumed (and that was based on the facts that human body does not produce omega-3 fatty acids, therefore they have to be consumed) that synthetically processed omega-3 might contribute to higher levels of absorbed omega-3 fatty acids. We know by now that more is not better. MORE SUPPLEMENTS that exceed the daily allowance for such doses can cause significant health risks. Omega-3 fatty acids interact with medications, as well. If you are taking fish oil, especially fish liver oil, vitamin D and vitamin E, you are at significantly higher risk for bleeding. When all these supplements are combined with blood thinning medications (anticoagulants) that many people take to prevent thrombosis or heart attacks, the outcome might be seriously bad because the blood clotting will be significantly affected.

None of the previously carried out clinical trials about benefits of supplemented omega-3 use has provided with statistically significant proof that such use is beneficial for any of these conditions, but healthy life style and consumption of omega-3 fatty acids from clean food sources is. Therefore, it is much more advisable to eat good food and stay away from supplements, unless your doctor has prescribed them. That might be a drug form that is different from the over-the-counter form and, therefore, it might work for you. Uncontrolled use of any kind of supplements when somebody is already on prescription medications can be DANGEROUS  and it CAN AFFECT THE WAY YOUR PRESCRIPTION MEDICATION WORKS. Always consult a doctor, assuming your doctor is aware of the newest scientific discoveries and follows up on developments in the area of synthetic vitamins and synthetic supplements.

US National Institute of Health publication https://nccih.nih.gov/health/omega3/introduction.htm

The truth is that synthetic supplements have a different chemical composition; it is not the same respective vitamin or mineral which we are absorbing from food. Therefore, the metabolism pathways and the way this supplement or vitamin act and behave in the body are not completely known. It is also believed that vitamins and minerals from natural sources work the way they do because food usually contains a set or combination of minerals, amino acids and vitamins in their natural form which is recognized by the body; and this recognition is due to the program which is set by our very individual DNA.

Next articles will review the problems with synthetic antioxidants, vitamin E (the only synthetic form which is available at pharmacies: alpha-tocopherol), vitamin C and some other supplements. If you do not know where to look for supplement and vitamin recalls (there are quite a lot of them), google Health Canada and FDA websites. Such lists are publicly available.

 

 

Are you wasting your money for supplements and vitamins without experiencing any benefits?

The multibillion industry of non-prescription food supplements and vitamins is most likely operating on assumptions. How so?

Absence of controlled clinical testing

Prescription drug has to undergo many stages of clinical trials: to obtain statistically significant trial results there has to be a sufficient research population, control groups, dose safety and tolerance testing and also estimates of benefits versus harm. That is why placement on the market of a prescription drug might take quite many years. When studies in animals have proven potentially safe use for humans, healthy volunteers will try the drug before it is assigned to people with a particular condition or disease. First phases are blinded and double-blinded when neither treating doctor, nor patient knows what they are receiving placebo or the active substance, and the effects of study drug are compared to placebo. Placebo is a drug that looks like the active treatment drug, but has no active substance. That allows excluding false improvement cases and accessing the success rate. Next phases (assuming that the drug has gotten so far) will compare doses or combination treatments. There can be both: dose safety testing and testing in combination. Only when the obtained results from controlled studies (controlled means the indicators and values are taken at baseline and periodically throughout the clinical trial and at the end of it and all results are appropriately documented and patients are monitored) can reveal significant benefit versus risk ratio, as well as statistically significant improvement, the drug would be approved for marketing and selling it.

That’s not the case with supplements: they are left on conscience of producer and manufactured at discretion of a company. Clinical testing and clinically proven in such cases might mean a small population with not properly recorded baseline indicators and improper monitoring throughout the testing period. The outcome of a study always depends on study subjects; that’s why there are meticulously elaborated inclusion and exclusion criteria in real clinical studies. Many supplements usually bypass the multi-patient testing since it is time-; labor- and cost-consuming.

As soon as the first synthetic vitamins were created and as soon as we realized the role and importance of these organic nutrients, it was assumed: there were no risks, but only benefits with their consumption for everybody.

The global market for complexes of vitamin compounds, minerals, herbs with vitamin compounds, enzymes, synthetic proteins and similar substances has become an uncontrollable, huge profits gaining monster. Can you trust a clinical testing that is carried out and paid for by the manufacturing company? That is a very doubtful testing for results because we are talking about billions of dollars in potential profits.

What is the danger?

Unlike any advertisement tells, it is by far not as safe as we believe to take supplements and vitamins, especially in the absence of proof of authenticity (buying online or from not certified provider). Virtually, anybody can manufacture non-prescription supplements because the regulations and standards for this type of products are not sufficiently regulated and controlled. The medical authorities become aware of harmful substance or risks associated with the use of some product ONLY after they receive reports about serious side-effects, illnesses caused by these products or even lethal cases. Do you really want to be the healthy volunteer who goes for it?

Supplementation is important for the treatment of certain health problems, especially clinically significant deficiencies that cause chain reactions in the body by inhibiting some processes; however, there is little evidence of nutritional benefit when used by otherwise healthy people.

The supplement market assumes we are all the same

Overdose or unnecessary consumption of such products can result in side effects. What global market of vitamins and other supplements does not take into account is the individual condition of a person, individual medical history, climate where one resides, nutrition or malnutrition history, specific genetic inheritance and so on, specific conditions and so on. We differ in any aspect: patient A could be absorbing some supplement very well, patient B experiences neither improvement, nor worsening with it, and patient C has side effects; and these differences will be due to their personal metabolism and thousands of other factors. Therefore, it is WRONG to assume that any supplement or vitamin will make you healthier. Vitamin A and E supplements do not only provide any health benefits for generally healthy individuals, but they may increase serious health risks. The wide-spread opinion that omega-3 supplements help maintaining heart health and overall health is somewhat doubtful, too; at least clinical trial (6 years long, in more than 12,000 patients) showed no efficacy as compared to placebo group. We also have to remember that under influence of health maintaining goals, lots of food products have added all kinds of synthetic supplements and vitamins, especially vitamin D and calcium.

Dangerous vitamins and supplements

The safest way to find out our body’s necessities

We need to know and we need to be aware on how our body works, what we are short of and what we have enough. The assumption that life time long consumption of supplements will make us disease-free and increase the life expectancy is not based on strong clinical proofs. It is based on assumption that more is better. We are becoming more knowledgeable thanks to quick lab tests, but once again: the body and mind love BALANCE. Not more, not less, but as much as needed. We receive this in a dose that is suitable for us personally when we consume balanced, nutrient-rich, fresh and organic food. The problem with organic food can be also a misleading labeling, well, use your common sense.

The only way to find out where we are standing is to ask your doctor for tests. If there is a clinically significant deficiency, you might need completely different form of this particular substance, not the over-the-counter version. Repeated testing will show whether you are absorbing any of this supplement or not. There are cases when people take iron supplements for prevention of anemia, but these supplements do not work at all because body does not recognize them in a form they are provided, and that is the main issue with all synthetically produced supplements and vitamins: it is not always that we will be making any use of them, even in case when no harm happens.

Are you obsessed with health issues?

If you are, you should be aware that consumption of supplements won’t have any benefits if you have a good health already. Consumption of nutrient-rich food will provide you with everything in a balanced and proper way. Whenever possible, we have to use the most natural, nothing added and nothing removed products.

wasting-money-for-supplements

I will continue with clinical trials, dose-dependent harms or benefits and explain why some supplements do not work as expected or do not work for every person in the next article.

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